The Effects of Insulin on the Microvasculature
The unifying hypothesis of this application is that microvascular endothelial dysfunction is present in type 2 diabetes and in insulin-resistant pre-diabetic states and is characterized by impaired insulin and substrate delivery to capillaries (impaired capillary recruitment) and by decreased nutrients/hormone exchange across the capillary endothelium. These studies, when successfully completed, should provide a more comprehensive understanding of the role of the microvasculature as a site of regulation of insulin action in health and insulin resistant states.
- Professor Gene Barrett - University of Virginia, USA
- Dr John Newman