Causes of Neuron Degeneration in Motor Neurone Disease

The major form of motor neurone disease is amyotrophic lateral sclerosis (ALS). This degenerative condition involves selective degeneration of motor neurons in the neocortex, brain stem and spinal cord. It is becoming increasingly clear that prior to motor neuron loss there is a substantial period of axonal and neuronal dysfunction, which could be targeted for therapeutic intervention. Using a combination of in vivo and in vitro techniques, as well as relevant transgenic mouse models and advanced cellular imaging, we are investigating the pathological processes underlying motor neuron degeneration. We have a particular focus on the role of excitotoxic mechanisms and disturbed neuron-glia interactions in the development of axonal dysfunction and pathology.

Related Diseases


Team Leaders

  • Associate Professor Tracey Dickson (Member)

Team Members

  • Dr Catherine Blizzard (Research Fellow)

Related Funding Bodies