What does our DNA have to do with brain cell loss in Multiple Sclerosis?

Multiple sclerosis is a complex disease and while many risk factors have been identified, the signalling pathways that initiate multiple sclerosis are unknown.  By performing whole genome sequencing of families with a high incidence of multiple sclerosis, we hope to identify rare genetic variants that will provide insight into the cause of multiple sclerosis.  Using induced pluripotent stem cell (iPSC) culture, electrophysiology, immunocytochemistry and CRISPR/Cas9 genome editing we are studying each genetic variant to identify the signalling pathways that are dysregulated and lead to the development of multiple sclerosis.