Protein-protein and protein ligand interactions

Understanding how proteins interact with one another, and with other ligands in the cell, is a central theme in biology.

Our group uses a wide range of biochemical and biophysical methods to investigate such interactions. Shown in the figure above, from left to right are:

  1. the &alpha-Hb binding face (red spheres) of &alpha-Hb binding protein (AHSP), mapped using NMR methods,
  2. the location of residues in AHSP that are critical (red) or important (orange) for high binding affinity determined from mutagenesis,
  3. the binding site for hemin (red/yellow) in human heme-binding protein 22 kDa (hbp-22).

Other methods used in the group include analytical ultracentrifugation, light scattering (dynamic and static), and isothermal titration calorimetry.

Research Groups


Team Leaders

  • Dr David Gell (Senior Research Fellow)