Oligodendrocyte Progenitor Cells - A New Target for Alzheimer's Disease
This is a potential Honours or PhD student project in the laboratory. There is growing evidence that amyloid toxicity induces significant neurodegeneration, and that the level of soluble amyloid correlates with memory deficit and disease severity in Alzheimer's Disease (AD). Most research into AD investigates the consequences of amyloid toxicity for neurons, however recent experimental evidence indicates that glial cells are also affected. Early oligodendrocyte and/or myelin damage may contribute directly to AD-induced neuronal loss, and accelerate the disease progression. This project tests the hypothesis that OPCs and oligodendrocytes are susceptible to AD-pathology.
Oligodendrocyte progenitor cells make new cells throughout life.
Related Diseases
Staff
Team Members
External Collaborators
- Professor David Attwell - University College, London
- Professor William Richardson -University College, London