Deciphering the mechanism of hydrogen sulfide-induced neuronal death
Recently the role of hydrogen sulphide (H2S) as a gasotransmitter stimulated wide interest owing to its involvement in Alzheimer's disease and ischemic stroke. Previously we demonstrated the importnace of functional ionotropic glutamate receptors (GluRs) by neurons is critical for H2S-mediated dose- and time-dependent injury. Moreover N-methyl-D-aspartate receptor (NMDAR) antagonists abolished the consequences of H2S-induced neuronal death. This study focuses on deciphering the downstream effects activation of NMDAR on H2S-mediated neuronal injury by analyzing the time-course of global gene profiling (5h, 15h and 24h) to provide a comprehensive description of the recruitment of NMDAR-mediated signaling.
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Staff
Senior Members
- Associate Professor Steve Cheung (Principal Research Fellow)
External Collaborators
- Professor PM Beart - Howard Florey Institute, University of Melbourne
- Professor PK Moore - Pharmaceutical Science Division, King's College London, UK