Sharman Group: Blood Pressure
High blood pressure is one of the leading contributors to death and disability from cardiovascular disease. The fundamental aim of the Blood Pressure Research Group is to improve health outcomes related to blood pressure.
To achieve this we are currently undertaking a program to:
- Determine the clinical value of new methods for the detection and management of high blood pressure
- Establish the role of low stress physical activity blood pressure as a clinical tool
- Understand the physiology of blood pressure and flow dynamics in the human cardiovascular system
Some members of the Blood Pressure Group also work in the Menzies Blood Pressure Clinic.
- Targeted LOWering of Central Blood Pressure in patients with hypertension: a randomised controlled trial (The LOW CBP study)
- Understanding the relationship between the heart & the arteries under resting & exercise conditions
- Unmasking masked hypertension with exercise blood pressure (The UNMASKED BP Study)
- Value of central blood pressure to guide treatment in people with high blood pressure (BP GUIDE Study)
Related Funding Bodies
- Menzies Quantum Fellowship
- National Health and Medical Research Council of Australia
- Diabetes Australia Research Trust
- Clifford Craig Medical Research Trust
- High Blood Pressure Research Council of Australia
- National Heart Foundation of Australia
- Professor James Sharman (Senior Research Fellow)
- Dr Martin Schultz (Postdoctoral Fellow)
- Ella Hoban (Menzies Blood Pressure Clinic Coordinator)
- Rachel Climie (PhD Student)
- Xiaoqing (Kelly) Peng (PhD Student)
- Dean Picone (PhD Student)
- Dr Nico Terblanche (PhD Student)
- Penny Veloudi (PhD Student)
- Phillip Cook (Honours Student)
- Kim Burleigh (Research Officer)
- Erin Nash (Research Officer)
- Sharni Jonston (Volunteer Laboratory Assistant)
- Dr Phil Roberts-Thomson (Cardiologist)
- Professor Tom Marwick (Cardiologist and Director, Menzies Institute for Medical Research)
- Associate Professor Velandai Srikanth, Monash University
- Professor Walter Abhayaratna, Canberra Hospital, ACT
- Dr Justin Davies, Imperial College, London
- Professor Alun Hughes, Imperial College, London
- Professor Michael Stowasser, University of Queensland
- *Schultz MG, Davies JE, Roberts-Thomson P, Black JA, Hughes AD, *Sharman JE. Exercise Central (Aortic) Blood Pressure Is Predominantly Driven by Forward Traveling Waves, Not Wave Reflection. Hypertension. 2013 May 28, 2013
- *Schultz MJ, *Otahal P, *Cleland V, *Blizzard L, *Marwick TH, *Sharman JE. Exercise hypertension, cardiovascular events and mortality in patients undergoing exercise stress testing: a systematic review and meta-analysis. Am J Hypertens 2013 Mar;26(3):357-66.
- *Climie RED, *Schultz MG, *Nikolic S, Ahuja K, Fell J, *Sharman JE. Validity and reliability of central blood pressure estimated by upper arm oscillometric cuff pressure. Am J Hypertens. 2012 Apr;25(4):414-20.
- Holland DJ, Sacre J, Leano RL, *Marwick TH, *Sharman JE. Contribution of Abnormal Central Blood Pressure to Left Ventricular Filling Pressure During Exercise in Patients with HFpEF. J Hypertens. 2011 Jul;29(7):1422-30.
- Head G, Mihailidou S, Duggan K, Beilin LJ, Berry N, Brown MA, Bune AJ, Cowley D, Chalmers JP, Howe PRC, Hodgson J, Ludbrook J, Mangoni A, McGrath B, *Nelson MR, *Sharman JE, Stowasser M. Definition of ambulatory blood pressure targets for diagnosis and treatment of hypertension in relation to clinic blood pressure: prospective cohort study. BMJ. 2010 Apr 14;340:c1104. doi: 10.1136/bmj.c1104.
- *Sharman JE, Davies JE, Jenkins C, Marwick TH. Augmentation index, left ventricular contractility and wave reflection. Hypertension. 2009;54:1099-1105.
- *Sharman JE, Brown J, Holland DJ, Macdonald G, Kostner K, Marwick TH. Influence of altered blood rheology on ventricular-vascular response to exercise. Hypertension. 2009 54:1092-1098.
- *Sharman JE, McEniery CM, Campbell R, Pusalkar P, Wilkinson IB, Coombes JS, Cockcroft JR. Nitric oxide does not significantly contribute to alterations in pulse pressure amplification during light aerobic exercise. Hypertension 2008;51:856-861.
- *Sharman JE, McEniery CM, Dhakam ZR, Coombes JS, Wilkinson IB, Cockcroft JR. Pulse pressure amplification during exercise is significantly reduced with age and hypercholesterolemia. J Hypertens 2007 Jun; 25(6):1249-54.
- *Sharman JE, Lim R, Qasem AM, Coombes JS, Burgess MI, Franco J, Garrahy P, Wilkinson IB, *Marwick TH. Validation of a generalized transfer function to noninvasively derive central blood pressure during exercise. Hypertension 2006:1203-1208.
- *Sharman JE, Fang ZY, Haluska B, *Stowasser M, Prins JB, *Marwick TH. Left ventricular mass in patients with type 2 diabetes mellitus is independently associated with central but not peripheral pulse pressure. Diabetes Care 2005; 28:937-939.
* Denotes Menzies Researcher