Devil Facial Tumour Disease: Woods Group
Research in the Cancer and Immunology Group is aimed at understanding how cancer cells escape detection by the immune system. Our immune system can detect and destroy cancer cells but occasionally some cancer cells have developed mechanisms to avoid immune detection. By understanding how, it might be possible to develop approaches to reduce cancer incidence. We are studying this question from separate approaches. One is by studying the ability of UVB-radiation to suppress the immune system and another by studying cancer cells, such as devil facial tumour disease cancer cells, that survive in the presence of a functional immune system.
Related Funding Bodies
- Professor Greg Woods (Principal Research Fellow)
- Dr Kathy Belov
- Dr Silvana Bettiol
- Gabby Brown
- Dr Vanessa Hayes
- Dr Alexandre Kreiss
- Dr Elizabeth Murchison
- Dr David Obendorf
- Dr Cesar Tovar
- Professor Konrad Muller
- *Woods GM, *Malley RC, Muller HK. The Skin Immune System and the challenge of tumour immunosurveillance. European Journal of Dermatology 2005; 15:63-9.
- *McGee HM, *Scott DK, *Woods GM. Neonatal exposure to UV-B radiation leads to a large reduction in Langerhans cell density, but by maturity, there is an enhanced ability of dendritic cells to stimulate T cells. Immunol Cell Biol 2006; 84, 259-266.
- *Woods GM, *Kreiss A, *Belov K, Siddle HV, *Obendorf DL, *Muller HK. The Immune Response of the Tasmanian Devil (Sarcophilus harrisii) and Devil Facial Tumour Disease. EcoHealth. 2007; 4 (3) 338-45.
- *Scott DK, Lord JR, Muller HK, *Malley RC, *Woods GM. Proteomics identifies enhanced expression of stefin A in neonatal murine skin compared to adults: functional implications. British Journal of Dermatology 2007; 156 : 1156-62
- *Norval M, *Malley RC, *Woods GM. Immune protection against photocarcinogenesis. Expert Review of Dermatology 2007; 2 : 543-547.
- Siddle HV, *Kreiss A, Eldridge MDB, Noonan E, Clarke CJ, Pyecroft S, *Woods GM, *Belov K. Transmission of a fatal clonal tumour by biting occurs due to depleted MHC diversity in a threatened carnivorous marsupial. PNAS. 2007; 104 (41) 16221-26.
- *Kreiss A, Fox N, Bergfeld J, *Quinn SJ, Pyecroft S, Wood GM. Assessment of cellular immune responses of healthy and diseased Tasmanian devils (Sarcophilus harrisii). Dev Comp Immunol. 2008; 32 544-553.
- *Muller HK, *Malley RC, *McGee HM, *Scott DK, Wozniak T, *Woods GM. Effect of UV radiation on the neonatal skin immune system - implications for melanoma. Photochem Photobiol 2008; 84(1) 47-54.
- *Stewart N, *Bettiol S, *Kreiss A, Fox N, *Woods GM. Mitogen induced responses in lymphocytes from platypus (Ornithorhyncus anatinus), the Tasmanian devil (Sarcophilus harrisii) and the eastern barred bandicoot (Perameles gunni). Austr Vet J. 2008; 86(10) 408-413.
- *Malley RC, Muller HK, Norval M, *Woods GM. Vitamin D3 deficiency enhances contact hypersensitivity in male but not in female mice. Cellular Immunology 2009; 255: 33-40.
- *Kreiss A, *Obendorf DL, Hemsley S, Canfield P, *Woods GM. Histology and immunohistochemistry of lymphoid tissues of the Tasmanian devil. The Anatomical Record. 2008; (accepted).